一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

1334763-80-2

Ethanone, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)- synthesis

1synthesis methods
614750-85-5 Synthesis
Phosphonic acid, P-[(6-Methyl-2-pyridinyl)(phenylaMino)Methyl]-, diphenyl ester

614750-85-5
21 suppliers
inquiry

130345-50-5 Synthesis
QUINOXALINE-6-CARBALDEHYDE

130345-50-5
166 suppliers
$24.00/100mg

Ethanone, 1-(6-Methyl-2-pyridinyl)-2-(6-quinoxalinyl)-

1334763-80-2
7 suppliers
inquiry

-

Yield:1334763-80-2 79%

Reaction Conditions:

Stage #1: diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate;quinoxaline-6-carbaldehydewith caesium carbonate in tetrahydrofuran;isopropyl alcohol at 20; for 16 h;
Stage #2: with hydrogenchloride in tetrahydrofuran;water;isopropyl alcohol; for 1 h;
Stage #3: with potassium hydroxide in water; pH=7 - 8;

Steps:

4.1.1. General procedure for the preparation of 1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethanone (11a) and 2-(2,3-dimethylquinoxalin-6-yl)-1-(6-methylpyridin-2-yl)ethanone (11b)

General procedure: To a stirred solution of 10a or 10b (18.97 mmol) in a mixture of THF (40 mL) and i-PrOH (10 mL), diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate (18.97 mmol) and Cs2CO3 (24.65 mmol) were added. The mixture was stirred at room temperature for 16 h, and to it, 3 N HCl (25 mL) was added dropwise over a period of 5 min. The reaction mixture was diluted with MTBE (30 mL). The aqueous layer was separated, and the organic layer was extracted with 1 N HCl (2 × 50 mL). The combined aqueous layer was neutralized with 50% aqueous KOH solution (pH 78) and extracted with EtOAc (3 × 100 mL). The EtOAc solution was dried over anhydrous Na2SO4, filtered, and evaporated to dryness under reduced pressure. The residue was purified by MPLC on silica gel using EtOAc/hexane as eluent to give the titled compound 11a or 11b as a light yellow solid.

References:

Jin, Cheng Hua;Sreenu, Domalapally;Krishnaiah, Maddeboina;Subrahmanyam, Vura Bala;Rao, Kota Sudhakar;Nagendra Mohan, Annaji Venkata;Park, Chul-Yong;Son, Jee-Yeon;Son, Do-Hyun;Park, Hyun-Ju;Sheen, Yhun Yhong;Kim, Dae-Kee [European Journal of Medicinal Chemistry,2011,vol. 46,# 9,p. 3917 - 3925] Location in patent:experimental part

东辽县| 鄂温| 沙湾县| 永新县| 遂平县| 合作市| 金山区| 齐河县| 定陶县| 泾阳县| 云浮市| 金沙县| 无棣县| 开封县| 临颍县| 武宁县| 满洲里市| 黔西县| 隆子县| 鄂托克前旗| 香河县| 富川| 滨州市| 新晃| 宣城市| 苏尼特右旗| 延安市| 孙吴县| 葫芦岛市| 梅河口市| 湘潭市| 名山县| 木兰县| 湄潭县| 涿鹿县| 东方市| 荔浦县| 三河市| 尉氏县| 九台市| 连云港市|