(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol synthesis
- Product Name:(R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol
- CAS Number:1434652-66-0
- Molecular formula:C14H20O4
- Molecular Weight:252.31
1434652-62-6
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1434652-66-0
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Yield:1434652-66-0 52%
Reaction Conditions:
with Venusil Chiral OD-H in ethanol;hexane;
Steps:
76 Synthesis of Compound 76.2.
Synthesis of Compound 76.2. [0802] The enantiomers of 76.1 (22 g) were resolved by chiral preparative HPLC under the following conditions (Gilson Gx 281): Column: Venusil Chiral OD-H, 21.1*25 cm, 5 μm; mobile phase: hexanes (0.2% TEA) and ethanol (0.2% TEA) (hold at 10% ethanol (0.2% TEA) for 13 min); detector: UV 220/254 nm. 11.4 g (52%) of 76.2 were obtained as a white solid.
References:
US2013/123231,2013,A1 Location in patent:Paragraph 0798; 0801; 0802
2081-44-9
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$6.00/1g
1434652-66-0
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135-02-4
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$10.00/10g
1434652-66-0
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141303-38-0
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1434652-66-0
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16750-63-3
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$66.09/100ml
1434652-66-0
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