2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride synthesis
- Product Name:2-(1 Lamda{2}-piperidin-4-yl)pyridin-4-yl dihydrochloride
- CAS Number:143924-45-2
- Molecular formula:C10H16Cl2N2
- Molecular Weight:235.1534
79099-07-3
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143924-45-2
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: 68 percent / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.1: 64 percent / Pd(PPh3)4 / tetrahydrofuran / 1.5 h / 60 °C
3.1: 99 percent / H2 / Pd/C / 1.5 h / 20 °C / 3102.89 Torr
4.1: 99 percent / HCl gas / ethyl acetate / -78 - 20 °C
References:
Patel, Meena V.;Kolasa, Teodozyj;Mortell, Kathleen;Matulenko, Mark A.;Hakeem, Ahmed A.;Rohde, Jeffrey J.;Nelson, Sherry L.;Cowart, Marlon D.;Nakane, Masaki;Miller, Loan N.;Uchic, Marie E.;Terranova, Marc A.;El-Kouhen, Odile F.;Donnelly-Roberts, Diana L.;Namovic, Marian T.;Hollingsworth, Peter R.;Chang, Renjie;Martino, Brenda R.;Wetter, Jill M.;Marsh, Kennan C.;Martin, Ruth;Darbyshire, John F.;Gintant, Gary;Hsieh, Gin C.;Moreland, Robert B.;Sullivan, James P.;Brioni, Jorge D.;Stewart, Andrew O. [Journal of Medicinal Chemistry,2006,vol. 49,# 25,p. 7450 - 7465]
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206446-49-3
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143924-45-2
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$165.00/250 mg
138647-49-1
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143924-45-2
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![3',6'-DIHYDRO-2'H-[2,4']BIPYRIDINYL-1'-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/90606-77-2.gif)
90606-77-2
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143924-45-2
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581-47-5
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$16.00/1g
143924-45-2
36 suppliers
$165.00/250 mg