METHYL 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLATE synthesis
- Product Name:METHYL 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLATE
- CAS Number:1447-13-8
- Molecular formula:C6H8Cl2O2
- Molecular Weight:183.03
67-66-3
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1447-13-8
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Yield:1447-13-8 88.7%
Reaction Conditions:
with benzyltriethylammonium bromide;sodium hydroxide at 20; for 4 h;
Steps:
3.1 cyclopropylation reaction
To a 500 ml three-neck round bottom flask equipped with a mechanical stirrer,30.3 g of methyl methacrylate (0.3 mol),100 ml of chloroform,0.5 g of triethylbenzylammonium bromide,160 ml of a 30% solution of sodium hydroxide,Followed by stirring at room temperature for 4 hours. Stirring was stopped,Layers are placed.The lower layer is organic phase,Most of the cycloaddition products are in the organic phase,The upper water layer,80 ml of concentrated hydrochloric acid was added dropwise to the aqueous layer with stirring to pH = 1,Stirred for another half hour, extracted with dichloromethane, the combined organic phases dried, evaporated to remove the solvent,To give 48.7 g of methyl 2,2-dichloro-1-methylcyclopropanecarboxylate,The yield was 88.7%Purity & gt; 95%
References:
CN104447293,2016,B Location in patent:Paragraph 0051-0053
67-66-3
0 suppliers
$39.79/500ml
80-62-6
633 suppliers
$21.00/25mL
1447-13-8
34 suppliers
$172.00/25ml
20101-83-1
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20101-83-1
0 suppliers
inquiry
1447-13-8
34 suppliers
$172.00/25ml
80-62-6
633 suppliers
$21.00/25mL
1447-13-8
34 suppliers
$172.00/25ml