ChemicalBook CAS DataBase List Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate

Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate synthesis

6synthesis methods

Product Name:Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate
CAS Number:146307-51-9
Molecular formula:C13H23NO4
Molecular Weight:257.33

24424-99-5

trans-Methyl-4-aMinocyclohexanecarboxylate

62456-15-9

Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate

146307-51-9

Methyl trans-4-aminocyclohexanecarboxylate (132 g, 401 mmol) was suspended in dichloromethane (1000 ml) under cooling conditions in an ice bath. Triethylamine (123 ml, 882 mmol) and di-tert-butyl dicarbonate (Boc2O, 101 ml, 440 mmol) were sequentially added to the suspension and the reaction was stirred for 10 minutes. Subsequently, the reaction mixture was transferred to room temperature and continued stirring for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was dissolved in aqueous citric acid solution (prepared by dissolving 50 g of citric acid monohydrate in 400 ml of water, pH adjusted to 4) and extracted with ethyl acetate. The organic phase was sequentially washed with water and dried with anhydrous magnesium sulfate. Finally, the organic phase was concentrated under reduced pressure to quantitatively obtain the target product methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate. The product was characterized by 1H-NMR (DMSO-d6) with the following chemical shift δ (ppm): 1.06-1.25 (m, 2H), 1.25-1.43 (m, 2H), 1.37 (s, 9H), 1.75-1.94 (m, 4H), 2.19 (tt, 1H, J = 11.7,3.9 Hz), 3.07-3.24 (m. 1H), 3.58 (s, 3H), 6.74 (d, 1H, J = 6.6 Hz).

24424-99-5 Synthesis

24424-99-5
860 suppliers
$13.50/25G

62456-15-9 Synthesis

62456-15-9
72 suppliers
$29.00/250mg

146307-51-9
115 suppliers
$6.00/100mg

Yield:146307-51-9 100%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 2.16667 h;Cooling with ice;

Steps:

3.1

Amine (132 g, 401 mmol) was suspended in dichloromethane (1000 ml) under ice-cooling. Triethylamine (123 ml, 882 mmol) and (Boc)₂O (101 ml, 440 mmol) were sequentially added thereto and stirred for 10 minutes. After that, the mixture was stirred at room temperature for 2 hours and the solvent was removed. The residue was poured into aqueous citric acid (citric acid monohydrate 50 g in water 400 ml) to become pH4 and extracted with ethyl acetate. The organic layer was washed with water and dried over magnesium sulfate anhydrous. The solvent was removed under reduced pressure to quantitatively give the target compound.¹H-NMR (DMSO-d6) δ ppm: 1.06-1.25 (m, 2H), 1.25-1.43 (m, 2H), 1.37 (s, 9H), 1.75-1.94 (m, 4H), 2.19 (tt, 1H, J=11.7, 3.9 Hz), 3.07-3.24 (m, 1H), 3.58 (s, 3H), 6.74 (d, 1H, J=6.6 Hz).

References:

US2010/273841,2010,A1 Location in patent:Page/Page column 21

15177-67-0 Synthesis