2-hydroxy-5-[2-[4-[(3-methylpyridin-2-yl)sulfamoyl]phenyl]ethynyl]benzoic acid synthesis
- Product Name:2-hydroxy-5-[2-[4-[(3-methylpyridin-2-yl)sulfamoyl]phenyl]ethynyl]benzoic acid
- CAS Number:149556-49-0
- Molecular formula:C21H16N2O5S
- Molecular Weight:408.43
149556-54-7
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Yield:-
Reaction Conditions:
with hydrogenchloride in potassium hydroxide;water;ethyl acetate;
Steps:
10.d 2-Hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoic acid
EXAMPLE 10d 2-Hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoic acid Ethyl 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate (15.5g, 35 mmol) was refluxed in potassium hydroxide (10 g, 0.15 mol) in water (100 ml) for 1 h. After cooling to ca 70° C., ethyl acetate (50 ml) was added and hydrochloric acid was added to reach pH 7-8. Cooling during stirring and then filration gave a solid that was dissolved in acetone (100 ml) and water (100 ml). The solution was acidified at ca 50° C. and cooled, filtered and washed with water. Yield 8.0 g (56%).
References:
US5302718,1994,A
![Benzoic acid, 2-(acetyloxy)-5-[2-[4-(chlorosulfonyl)phenyl]ethynyl]-, ethyl ester](/CAS/20210305/GIF/149556-90-1.gif)