(16α-bromine)-3α-Dehydroepiandrosterone synthesis
- Product Name:(16α-bromine)-3α-Dehydroepiandrosterone
- CAS Number:1093-91-0
- Molecular formula:C19H27BrO2
- Molecular Weight:367.3205
53-43-0
590 suppliers
$27.00/10g
1093-91-0
8 suppliers
inquiry
Yield:1093-91-0 97%
Reaction Conditions:
with copper(ll) bromide in methanol at 70; for 12 h;
Steps:
2.1. General procedure for the synthesis of compounds 3, 4
General procedure: A mixture of dehydroepiandrosterone 1 (5.00 g, 17.40 mmol) and CuBr2 (11.50 g,51.60 mmol, 3.00 eq.) in methanol (100 mL) was stirred at 70 for 12 h andmonitored by TLC. After cooling, the inorganic salt was filtered off. The filtrate wasevaporated in vacuo. The residue was dissolved in DCM (100 mL), then washed with brine(20 mL × 3). The organic phase was separated and dried over anhydrous Na2SO4. Then thesolvent was evaporated in vacuo and the crude product was purified by flash columnchromatography to give the title compound 3 as a white solid (6.20 g, 97%).
References:
Zhao, Jian-Wei;Wu, Zeng-Hui;Guo, Jia-Wen;Huang, Ming-Jie;You, Ya-Zhen;Liu, Hong-Min;Huang, Li-Hua [European Journal of Medicinal Chemistry,2019,vol. 181,art. no. 111520] Location in patent:supporting information
853-23-6
317 suppliers
$28.00/5g
1093-91-0
8 suppliers
inquiry
24335-49-7
0 suppliers
inquiry
1093-91-0
8 suppliers
inquiry
74644-60-3
0 suppliers
inquiry
1232-73-1
19 suppliers
inquiry
1093-91-0
8 suppliers
inquiry
![(3S,8R,9S,10R,13S,14S,17R)-3,17-dihydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-16-one](/CAS/GIF/1159-66-6.gif)
1159-66-6
7 suppliers
inquiry