一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester
1613382-10-7

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester synthesis

5synthesis methods
-

Yield:1613382-10-7 57%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine;HATU in N,N-dimethyl-formamide at 20;Inert atmosphere;

Steps:

4 Example 4- Synthesis of tri-tert-butyl 2,2',2'-(10-(2-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Example 4- Synthesis of tri-tert-butyl 2,2',2'-(10-(2-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
To a solution of product 2-(4,7,10-Tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid (572.7 mg, 1 mmol) in dry DMF (15 mL), amino-maleimide 137 (483.3 mg, 1 mmol) was added with HATU (272 mg, 1.4 mmol) and DIPEA (360 μL, 1.84 mmol).
The mixture was stirred overnight at room temperature.
After removing the solvent under the vacuum, the crude product was purified by flash chromatography on silica gel (CH2Cl2/MeOH, 90:10) to give compound tri-tert-butyl 2,2',2'-(10-(2-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate as a white foam (396 mg, 57 %).
Rf : 0.3 (CH2Cl2/MeOH, 90:10).
1H NMR (300MHz, CDCl3) δ 8.30 (b, 1H, NH), 6.86 (s,2H, H6'), 3.78-3.54 (br, 4H, H3', H4'), 3.54 (br, 4H, H13, H1'), 3.48 (br, 4H, H8), 3.09-2.99 (m, 8H, H2, H3), 2.97-2.86 (m, 8H, H5, H6), 1.46 (s, 18H, H12), 1.45 (s, 9H, H17).
13C NMR (75MHz, CDCl3) δ 171.6 (C2'), 171.0 (C5'), 170.4 (C9, C14), 134.2 (C6'), 81.5 (C16), 81.3 (C11), 57.8 (C1'), 55.7-55.2 (C8, C13), 54.1-51.5 (C2, C3), 51.0-48.9 (C5, C6), 38.0 (C4'), 32.7 (C3'), 27.8 (C17), 27.6 (C12).
MS (ESI) : m/z 695 [M + H]+.

References:

EP2740491,2014,A1 Location in patent:Paragraph 0131; 0132

192635-89-5 Synthesis
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-diMethylethyl) phenylMethyl ester

192635-89-5
7 suppliers
inquiry

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-2-oxoethyl]-, 1,4,7-tris(1,1-dimethylethyl) ester

1613382-10-7
43 suppliers
inquiry

维西| 崇州市| 水富县| 昭平县| 龙岩市| 英德市| 沁源县| 辉县市| 台北县| 云和县| 太湖县| 聂拉木县| 平和县| 甘南县| 梅河口市| 灵武市| 德惠市| 平阳县| 台中市| 肃宁县| 巴里| 普宁市| 成都市| 曲水县| 白朗县| 高尔夫| 沁源县| 延津县| 墨江| 桃园市| 米易县| 巴马| 富顺县| 兴城市| 通化市| 阿坝县| 张北县| 婺源县| 正镶白旗| 邵阳县| 仁怀市|