一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1H-Pyrazole-3-carboxylicacid,5-ethyl-1-methyl-,ethylester(9CI)
165744-14-9

1H-Pyrazole-3-carboxylicacid,5-ethyl-1-methyl-,ethylester(9CI) synthesis

4synthesis methods
-

Yield:165744-14-9 95.5% ,128537-26-8 12.6%

Reaction Conditions:

with glacial acetic acid at 0 - 15; for 5 h;

Steps:

5.1 Step 1

To a solution of ethyl 2, 4-dioxohexanoate (10.0 g, 58.1 mmol, 1 eq) in AcOH (65.7 g, 1.09 mol, 62.6 mL, 18.8 eq was added methylhydrazine (7.45 g, 64.7 mmol, 8.51 mL, 40% purity, 1.11 eq) at 0 °C. The mixture was stirred at 15 °C for 5 hours. LCMS showed desired MS in main peak. The mixture was concentrated in vacuum to give crude. The residue was purified by combi flash chromatography (120 g silica gel column, EtOAc in PE from 0% to 50%). Ethyl 5 -ethyl- 1 -methyl -pyrazole-3 -carboxylate (10.1 g, 55.5 mmol, 95.5% yield) was obtained as yellow oil. NMR (400MHz, CDCh) δ = 6.59 (s, 1 H), 4.39 (q, J= 14.4, 7.2 Hz,2 H), 3.85 (s, 3 H), 2.62 (q, J = 14.4, 7.2 Hz, 2 H), 1.39 (t, J = 7.2 Hz, 3 H), 1.28 (t, J = 7.6 Hz,3 H). Ethyl 5-ethyl-2-methyl-pyrazole-3-carboxylate (1.33 g, 7.30 mmol, 12.6% yield) was obtained as colorless oil. 1 H NMR (400 MHz, CDCh) δ = 6.65 (s, 1 H), 4.34 (q, 7=7.2 Hz, 2 H), 4.18 - 4.11 (m, 4 H), 2.65 (q, 7 = 15.2, 7.6 Hz, 2 H), 1.38 (t, 7 = 7.2 Hz, 3 H), 1.25 (t, 7 = 7.6 Hz, 3 H)

References:

WO2022/133037,2022,A1 Location in patent:Paragraph 0685-0686

1H-Pyrazole-3-carboxylicacid,5-ethyl-1-methyl-,ethylester(9CI) Related Search:

宜阳县| 普格县| 阿拉善右旗| 青浦区| 菏泽市| 贺州市| 溧阳市| 兴义市| 南宫市| 东丰县| 休宁县| 上林县| 六盘水市| 本溪市| 崇仁县| 阿克苏市| 钟山县| 富民县| 鄯善县| 于田县| 曲麻莱县| 朝阳区| 三原县| 通渭县| 清远市| 无棣县| 阳春市| 东辽县| 遵化市| 康保县| 潮安县| 福建省| 清水河县| 堆龙德庆县| 容城县| 小金县| 林甸县| 桃源县| 永嘉县| 华蓥市| 和田市|