O-Desmorpholinopropyl Gefitinib synthesis
- Product Name:O-Desmorpholinopropyl Gefitinib
- CAS Number:184475-71-6
- Molecular formula:C15H11ClFN3O2
- Molecular Weight:319.72
788136-89-0
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184475-71-6
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Yield:184475-71-6 95.3%
Reaction Conditions:
with sodium methoxide in methanol; for 3 h;Reflux;
Steps:
1.5 5) Preparation of 4- (3-chloro-4-fluoro) phenylamino-6-hydroxy-7-methoxyquinazoline (6)
To the reaction vessel was added 4- (3-chloro-4-fluoro) phenylamino-6-carbethoxy-7-methoxyquinazoline (3.61 g,10mmol), dissolved in 30mL methanol, added sodium methoxide (2.7g, 50mmol), stirred evenly, heated to reflux, reaction 3hour. After completion of the reaction, the solid was removed by filtration, and the solid was cooled to give 4- (3-chloro-4-fluoro) phenylamino-6-hydroxy-7-methoxy Ylquinazoline was obtained in a yield of 95.3%.
References:
CN106045980,2016,A Location in patent:Paragraph 0027; 0028; 0029
913819-12-2
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184475-71-6
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367-21-5
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179688-53-0
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184475-71-6
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$5.00/250mg
179688-53-0
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184475-71-6
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13794-72-4
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184475-71-6
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