2-Methylthio-4-trifluoroMethylbenzoic Acid Methyl Ester synthesis
- Product Name:2-Methylthio-4-trifluoroMethylbenzoic Acid Methyl Ester
- CAS Number:192805-69-9
- Molecular formula:C10H9F3O2S
- Molecular Weight:250.24
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Yield: 89%
Reaction Conditions:
with hydrogenchloride at 50; for 5 h;
Steps:
Example 3
In a 500-ml four-neck flask, 128 g of methanol and 217 g of o-methylthio trifluoromethylbenzonitrile were heated to 50° C., and a flow rate of 0.5 L/h of hydrochloric acid gas was used to react for 5 h.About 60 g of methanol (approximately 1/2 of the methanol is depressurized) is desorbed at P=-0.09 Mpa, and the mixture is cooled and filtered. The cake is washed 3 times with 60 g of water, and the product [1] is obtained.Add about 230 g of dried [1] and 434 g of toluene to a four-neck bottle and add 25 g of potassium hydroxide in 4 batches at 30°C.1h After the addition, the reaction 3h,Acidify to pH=2 with hydrochloric acid, suction filtration, washing the organic phase with 60g water 3 times, liquid separation, desolvation to a solid precipitation, cooling down to 0-5 °C precipitation product, suction filtration, product content 98%, yield 89% .
References:
Jingbo Agrochemical Technology Co., Ltd.;Liu Haijing;Wei Nengchun;Dai Ronghua;Wang Jiangang;Yu Lianyou CN107417587, 2017, A Location in patent:Paragraph 0011-0012; 0013-0014; 0015-0016
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192805-69-9
35 suppliers
$336.00/100mg
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228418-45-9
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192805-69-9
35 suppliers
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