一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate
197142-33-9

tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate synthesis

11synthesis methods
197142-34-0 Synthesis
N-Boc-L-trans-4,5-Methanoproline

197142-34-0
102 suppliers
$28.00/100mg

tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

197142-33-9
16 suppliers
inquiry

-

Yield:197142-33-9 91%

Reaction Conditions:

Stage #1: (1R,3S,5R)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acidwith borane-THF in tetrahydrofuran at 0; for 3.5 h;Reflux;
Stage #2: with methanol in tetrahydrofuran at 0;

Steps:

61

To a solution of (lR,3S,5R)-2-(tert-butoxycarbonyl)-2- azabicyclo[3.1.0]hexane-3-carboxylic acid (9.85 g, 43.3 mmol) in THF (200 mL) at 0 °C was added dropwise borane-methyl sulfide complex (282 mL, 563 mmol) over 30 min. The ice bath was removed, the mixture was stirred for lh and then heated at reflux for 2h. The mixture was cooled to 0 °C, slowly quenched with methanol (-200 mL) and concentrated under vacuum. The residue was dissolved in DCM and washed with water (emulsion), IN HC1, sat NaHCC aq, and brine. The organic layer was dried over a2S04, filtered and concentrated to yield (lR,3S,5R)-/er/-butyl 3-(hydroxymethyl)-2- azabicyclo[3.1.0]hexane-2-carboxylate (8.43 g, 39.5 mmol, 91 % yield) as colorless oil. LC-MS retention time 1.398 min; m/z 236.20 [M+Na]+. LC data was recorded on a Shimadzu LC-10AS liquid chromatograph equipped with a Waters Sunfire 5u CI 8 4.6x30mm column using a SPD-10AV UV-Vis detector at a detector wave length of 220nM. The elution conditions employed a flow rate of 4 mL/min, a gradient of 100% Solvent A / 0% Solvent B to 0% Solvent A / 100% Solvent B, a gradient time of 2 min, a hold time of 1 min and an analysis time of 4 min where Solvent A was 10% methanol / 90% water / 0.1% TFA and Solvent B was 90% methanol/ 10% water / 0.1% TFA. MS data was determined using a MICROMASS Platform for LC in electrospray mode. 1H NMR (500 MHz, MeOD) δ ppm 3.72 - 3.79 (m, 1H), 3.52 - 3.64 (m, 3H), 3.15 - 3.24 (m, 1H), 2.00 - 2.08 (m, 1H), 1.62 - 1.72 (m, 1H), 1.54 - 1.62 (m, 1H), 1.45 - 1.51 (m, 9H), 0.84 (br s, 1H), 0.36 (td, J=5.0, 2.4 Hz, 1H).

References:

WO2011/59850,2011,A1 Location in patent:Page/Page column 215

132974-83-5 Synthesis
(2S)-2-[[[(1,1-DIMETHYLETHYL)DIPHENYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE

132974-83-5
19 suppliers
inquiry

tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate

197142-33-9
16 suppliers
inquiry

tert-butyl (3S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate Related Search:

句容市| 广南县| 阳城县| 岳普湖县| 古交市| 玉环县| 门源| 板桥市| 松潘县| 凤阳县| 容城县| 九台市| 张北县| 邳州市| 沐川县| 游戏| 化德县| 阿拉善右旗| 唐河县| 云南省| 清原| 娱乐| 唐山市| 清河县| 清涧县| 贵阳市| 东方市| 江陵县| 五大连池市| 呼玛县| 军事| 天等县| 灵宝市| 普兰店市| 农安县| 沾益县| 来安县| 望谟县| 曲阳县| 化州市| 屏边|