2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole synthesis
- Product Name:2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole
- CAS Number:19735-44-5
- Molecular formula:C12H11F3N2
- Molecular Weight:240.22
Yield:19735-44-5 66%
Reaction Conditions:
with boron trifluoride diethyl etherate;acetic acid at 20 - 90; for 2 h;Inert atmosphere;Fischer indole synthesis;
References:
Dossetter, Alexander G.;Beeley, Howard;Bowyer, Jonathan;Cook, Calum R.;Crawford, James J.;Finlayson, Jonathan E.;Heron, Nicola M.;Heyes, Christine;Highton, Adrian J.;Hudson, Julian A.;Jestel, Anja;Kenny, Peter W.;Krapp, Stephan;Martin, Scott;MacFaul, Philip A.;McGuire, Thomas M.;Gutierrez, Pablo Morentin;Morley, Andrew D.;Morris, Jeffrey J.;Page, Ken M.;Ribeiro, Lyn Rosenbrier;Sawney, Helen;Steinbacher, Stefan;Smith, Caroline;Vickers, Madeleine [Journal of Medicinal Chemistry,2012,vol. 55,# 14,p. 6363 - 6374] Location in patent:supporting information; experimental part
