1H-Inden-1-one synthesis
- Product Name:1H-Inden-1-one
- CAS Number:480-90-0
- Molecular formula:C9H6O
- Molecular Weight:130.14
83-33-0
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480-90-0
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Yield:480-90-0 70%
Reaction Conditions:
Stage #1:inden-1-one with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in tetrachloromethane for 2.5 h;Reflux;
Stage #2: with triethylamine in tetrachloromethane at 0;
Steps:
Representative experimental procedure for the Synthesis of benzo[c]fluorenone
General procedure: NBS (195 mg, 1.1 mmol) and AIBN (2 mg, 0.01 mmol) were added to a CCl4 solution (4 ml) of the 6-methoxyindanone (162 mg, 1 mmol). The resulting mixture was stirred at reflux temperature for 2.5 h, then cooled and filtered through Celite, which was then washed with CCl4. The filtrate was cooled to 0 °C and treated with triethylamine (0.28 mL, 2.0 mmol) overnight, then concentrated in vacuuo. Chromatography of the residue (1 : 9~1 : 4 EtOAc/hexanes) afforded 97 mg (60%) of enone 1a as the pink oil which solidified as light red solid in refrigerator.
References:
Zheng, Shuyan;Tan, Hongsheng;Zhang, Xiaoguang;Yu, Chunhui;Shen, Zhengwu [Tetrahedron Letters,2014,vol. 55,# 5,p. 975 - 978] Location in patent:supporting information
40774-41-2
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480-90-0
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6710-43-6
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480-90-0
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![1H-Indene, 3-[(trimethylsilyl)oxy]-](/CAS/20210111/GIF/31928-64-0.gif)
31928-64-0
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480-90-0
35 suppliers
$60.00/50mg