(1H-INDOL-3-YLMETHYLENE)MALONONITRILE synthesis
- Product Name:(1H-INDOL-3-YLMETHYLENE)MALONONITRILE
- CAS Number:75629-62-8
- Molecular formula:C12H7N3
- Molecular Weight:193.2
Yield:75629-62-8 97%
Reaction Conditions:
in water at 20; for 0.166667 h;Green chemistry;Knoevenagel Condensation;
Steps:
2.1.1. Synthesis of 2-benzylidenemalononitrile and of 2-(2-oxo-indolin-3-ylidene) malononitrile derivatives
General procedure: Malononitrile (66 mg, 1 mmol) and 2,4-dichlorobenzaldehyde (223 mg, 1 mmol) were taken in pestle-mortar and mixed in 1:1 molar ratio in PEG-400/water as a solvent. After 10 minutes of grinding yellowish solid was obtained which was washed with wa- ter/ethanol (2 ×10 mL) and the reaction was monitored by TLC us- ing hexane and acetyl acetate (8:2) as the eluent and silica gel as stationary phase. TLC plates were visualized in an iodine chamber. After air drying and recrystallization in ethanol for 24 h, a white crystalline solid was obtained with high yield (96-99%) and char- acterized (Supplementary information) Scheme 1 and Table 1 .
References:
Ahmad, Rumana;Azad, Iqbal;Kamal, Azhar;Khan, Abdul Rahman;Khan, Tahmeena;Nasibullah, Malik [Journal of Molecular Structure,2021,vol. 1228,art. no. 129451]
