2,2'-Bipyridine synthesis
- Product Name:2,2'-Bipyridine
- CAS Number:366-18-7
- Molecular formula:C10H8N2
- Molecular Weight:156.18
Yield:366-18-7 96.7%
Reaction Conditions:
with dmap;copper(II) ethylacetoacetate;C26H36NP;silver(I) acetate in 1,2-dichloro-ethane at 90; for 8 h;Reagent/catalyst;
Steps:
3 Example 3: 2,2'-bipyridyl
At room temperature, the reactor proper amount of 1,2-dichloroethane, was added pyridine-2-carboxylic acid chloride 100mmol, 200mmol n-butylamine, 15mmol copper(II) ethylacetoacetate, 10mmol ligands L1,200mmol dimethylaminopyridine and 60mmol silver acetate, stirring heated to 90 , and the temperatureThe reaction was continued for 8 hours with stirring. TheAfter the completion of the reaction, the reaction system was allowed to cool to room temperature and washed thoroughly with deionized water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography, The mixture of n-butanol and ethyl acetate in a volume ratio of 1: 5 gave the compound of formula (I) 2,2'-bipyridine in a yield of 96.7%.
References:
CN104529879,2016,B Location in patent:Paragraph 0058; 0059; 0060; 0061; 0062; 0063
5029-67-4
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