2,2-DIFLUOROPROPIONAMIDE synthesis
- Product Name:2,2-DIFLUOROPROPIONAMIDE
- CAS Number:49781-48-8
- Molecular formula:C3H5F2NO
- Molecular Weight:109.07
373-96-6
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$13.00/1g
49781-48-8
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$55.00/50mg
Yield:49781-48-8 80.8%
Reaction Conditions:
with ammonia in methanol at 20;Inert atmosphere;Heating;
Steps:
2 Example 2 Preparation of 5,5-difluoro-4-oxo-trans-2-hexenal
The synthetic route of the compound 5,5-difluoro-4-oxo-trans-2-hexenal in the present invention is shown in Figure 3. In a 100mL three-necked flask, add 2g (18.18mmol) of 2,2-difluoropropionic acid and 30mL of dry methanol solution, replace the air in the three-necked flask with nitrogen, pass in ammonia gas and amination reaction for 24h. The reaction temperature is room temperature. 1.6 g of 2,2-difluoropropionamide was produced with a yield of 80.8%.1.6 g (14.68mmol) of 2,2-difluoropropionamide was dissolved in 25mL of toluene solution and dehydrated into 2,2-difluoropropionitrile in the presence of P2O5. 3,3-difluoro-2-butanone can be synthesized by hydrolyzing the generated 2,2-difluoropropionitrile with methylmagnesium iodide, with a yield of 73.6%.
References:
CN112094181,2020,A Location in patent:Paragraph 0028-0030
79-37-8
478 suppliers
$17.67/10gm:
373-96-6
235 suppliers
$13.00/1g
49781-48-8
36 suppliers
$55.00/50mg