2,2'-Dihydroxy-4,4'-dimethoxybenzophenone synthesis
- Product Name:2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
- CAS Number:131-54-4
- Molecular formula:C15H14O5
- Molecular Weight:274.27
Yield:131-54-4 130 kg
Reaction Conditions:
with zinc(II) chloride in ethanol;1,2-dichloro-ethane at 45 - 50; for 8 h;Industrial scale;
Steps:
1.1
methylation reaction: To the reaction kettle was charged 123 kg of 2, 2 ', 4,4'-tetrahydroxybenzophenone, 2.95 kg of zinc chloride and 590 L of mixed solvent prepared from 295 L of dichloroethane and 295 L of anhydrous ethanol, Dissolved, heated to 45 ~ 50 ° C, dropping dimethyl sulfate 148kg, 2h drop is completed, Insulation reaction 6h; Cooling to room temperature, add water 148L stirring dissolved, and then standing stratification, separation of the organic phase, the aqueous phase extracted with dichloroethane twice, each amount of 50L, combine the organic phase, distillation recovery solvent, cooling crystallization, , 2'-dihydroxy-4,4'-dimethoxybenzophenone (about 130kg) and the yield of 95% (calculated as 2,2',4,4'-tetrahydroxybenzophenone)
References:
CN104262209,2016,B Location in patent:Paragraph 0006; 0025; 0026
673-22-3
495 suppliers
$5.00/1g
131-54-4
340 suppliers
$12.00/5g
673-22-3
495 suppliers
$5.00/1g
90-02-8
480 suppliers
$9.00/1g
131-54-4
340 suppliers
$12.00/5g
835-11-0
124 suppliers
$28.00/1g
131-53-3
278 suppliers
$10.00/5g
![Benzene, [(broModifluoroMethyl)thio]-](/CAS/20150408/GIF/78031-08-0.gif)
108-98-5
0 suppliers
$21.10/10g
131-54-4
340 suppliers
$12.00/5g