2,2-DIPHENYLETHYL ISOTHIOCYANATE synthesis
- Product Name:2,2-DIPHENYLETHYL ISOTHIOCYANATE
- CAS Number:34634-22-5
- Molecular formula:C15H13NS
- Molecular Weight:239.34
463-71-8
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$32.00/10g
3963-62-0
157 suppliers
$10.00/1g
34634-22-5
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$46.00/250mg
Yield:34634-22-5 98%
Reaction Conditions:
with sodium hydrogencarbonate in dichloromethane at 20; for 0.5 h;
Steps:
4.2.5. General procedure for the synthesis of the isothiocyanates 83-88
General procedure: A solution of the respective amine (14e16 or 31e33, 1 equiv) inDCM was added to a saturated solution of NaHCO3 at rt. Subsequently,thiophosgene (1.1 equiv) was added dropwise and thereaction was stirred vigorously for 30 min at rt. The organic layerwas washed with H2O, brine and dried over Na2SO4. The solvent was removed under reduced pressure and the crude product waspurified with column chromatography (EtOAc/PE 5/95).
References:
Biselli, Sabrina;Bresinsky, Merlin;Buschauer, Armin;Forster, Lisa;Honisch, Claudia;Pockes, Steffen;Tropmann, Katharina;Bernhardt, Günther [European Journal of Medicinal Chemistry,2021,vol. 214,art. no. 113190] Location in patent:supporting information
75-15-0
273 suppliers
$40.00/100g
3963-62-0
157 suppliers
$10.00/1g
34634-22-5
43 suppliers
$46.00/250mg
3963-62-0
157 suppliers
$10.00/1g
34634-22-5
43 suppliers
$46.00/250mg