2-(2-Ethoxyphenoxy)ethyl Methanesulfonate synthesis
- Product Name:2-(2-Ethoxyphenoxy)ethyl Methanesulfonate
- CAS Number:169506-15-4
- Molecular formula:C11H16O5S
- Molecular Weight:260.31
Yield:169506-15-4 87%
Reaction Conditions:
with pyridine at 0 - 20; for 1 h;
Steps:
1.2 2step: the manufacture of 2 - (2 - ethoxyphenoxy ) ethyl methansulfonate .
Afterthe pyridine (200ml) was added to obtained 2 - (2- ethoxyphenoxy) ethanols (50.0g,0.274mol, 1.0eq) at 1 step and it altogether dissolved it cooled at 0. Methanesulfonyl chlorides(35.0ml, 0.453mol, 1.65eq) were dipped from the gradually to the cooledsolution and it was stirred for 1 hour while it heated to the slowly to the room temperature (20). The solid which wasgenerated after it dipped the water (350ml) as the gradually after it cooledthe above-mentioned stirred solution at 0 was filtered and 2 - (2- ethoxyphenoxy) ethylmethane sulfonate was obtained (62g, and the yield 87%). 2-(2-) NMR . Theobtained NMR peak of 2 - (2- ethoxyphenoxy) ethyl methane sulfonate showed uplike the next.
References:
Boryung Pharmaceutical Co., Ltd;Kim, Ji Han;Myung, Jae Hyok;Lee, Jun Kwang;Sun, Yong Ho;Kim, Hak Do KR101525493, 2015, B1 Location in patent:Paragraph 0072; 0089-0091
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