2,3-Diaminopyridine synthesis
- Product Name:2,3-Diaminopyridine
- CAS Number:452-58-4
- Molecular formula:C5H7N3
- Molecular Weight:109.13
6298-19-7
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$6.00/5g
452-58-4
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$14.00/1g
Yield:452-58-4 60%
Reaction Conditions:
with zinc ammonium chloride at 220; for 5 h;Autoclave;
Steps:
10 Example 10: Substrate expansion
2-Chloro-3-aminopyridine 5g (38.9 mmol, 1.0eq), zinc ammonium chloride 24.3g (116.7 mmol, 3.0eq), placed in an autoclave, heated to 220°C in an external bath, kept stirring, after 5h The reaction is complete. Add 100ml purified water to the system, extract the water phase twice with 100mL MTBE, and adjust the pH of the water phase to 8-9 with sodium hydroxide. A large amount of solids precipitate out. The target product 2.50g is obtained by filtration with a yield of 60%.
References:
Kailaiying Pharmaceutical Group (Tianjin) Co., Ltd.;Zhang Enxuan;Liu Zhiqing;Li Chao;Xiao Yi;Lu Jiangping CN111732536, 2020, A Location in patent:Paragraph 0053-0054
4214-75-9
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452-58-4
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15367-16-5
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452-58-4
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101458-28-0
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452-58-4
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3723-70-4
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$85.43/0.5g
452-58-4
474 suppliers
$14.00/1g