2,3-EPOXYPROPYL-4-METHOXYPHENYL ETHER synthesis
- Product Name:2,3-EPOXYPROPYL-4-METHOXYPHENYL ETHER
- CAS Number:2211-94-1
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield: 97.3%
Reaction Conditions:
Stage #1:4-methoxy-phenol with potassium carbonate in acetone at 20; for 0.5 h;
Stage #2:epichlorohydrin in acetone at 60 - 65; for 72 h;
Steps:
1.A [Example 1] Synthesis of Diacylglycerol Lactone Compound (EC-A129)
A. As shown in Reaction 1a below, 50 g (402.77 mmole) of 4-methoxyphenol was dissolved in 1500 ml of acetone. Then, 278 g (2013.8 mmole) of K2CO3 was added and stirred at room temperature for 30 minutes. 126 ml (1611.1 mmole) of epichlorohydrin was added to the 4-methoxyphenol solution, the temperature was raised to 60 to 65° C., and refluxed for 72 hours. The reaction was confirmed by TLC (ethylacetate(EA):hexane(Hex)=1:9). When the reaction was completed, the reaction solution was filtered by a celite filter, the filtrate was concentrated. The concentrate was purified with a flash column (eluent:ethyl acetate(EA):hexane(Hex)=1:10 (volume ratio) mixture) to obtain 68 g of the target compound (yield: 97.3%)
References:
ENZYCHEM LIFESCIENCES CORPORATION;SOHN, Ki Young;KIM, Jae Wha;YOON, Sun Young;YOO, Chang Hyun;JEONG, Jin Seon US2021/2242, 2021, A1 Location in patent:Paragraph 0034
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2211-94-1
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2211-94-1
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150-76-5
822 suppliers
$5.00/5 g
2211-94-1
88 suppliers
$46.10/5g