2,4,6-TRIPHENYLPYRIDINE synthesis
- Product Name:2,4,6-TRIPHENYLPYRIDINE
- CAS Number:580-35-8
- Molecular formula:C23H17N
- Molecular Weight:307.39
100-44-7
643 suppliers
$13.50/250G
98-86-2
797 suppliers
$9.00/5g
580-35-8
94 suppliers
$45.00/2.5mg
Yield: 97%
Reaction Conditions:
with ammonium acetate in neat (no solvent) at 150; for 8 h;Kroehnke Pyridine Synthesis;Solvent;Temperature;
Steps:
General Procedure for the Preparation of 2,4,6-Triarylpyridines3a-r, Exemplified with Compound 3a
General procedure: A mixture of acetophenone (1 mmol), benzyl chloride (2 mmol),and NH4OAc (3 mmol) in a 5 mL round-bottomed flask wasmagnetically stirred at 150 °C for 8 h. Progress of the reactionwas followed by TLC monitoring. The reaction mixture wascooled to ambient temperature, H2O (2.5 mL) was added, andthe product was extracted into CH2Cl2 (2 2.5 mL). The combinedorganic phases were dried over Na2SO4, filtered, thesolvent was removed, and the residue was purified by crystallizationfrom absolute EtOH. TAP 3b,c,k-m were purified by column chromatography usingn-hexane-EtOAc (6:1) as eluent. The solvent was removed, andthe solid residue was recrystallized from absolute EtOH.
References:
Adib, Mehdi;Ayashi, Neda;Mirzaei, Peiman [Synlett,2016,vol. 27,# 3,art. no. ST-2015-D0638-L,p. 417 - 421]
98-86-2
797 suppliers
$9.00/5g
100-51-6
1442 suppliers
$5.00/100g
580-35-8
94 suppliers
$45.00/2.5mg