2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE synthesis
- Product Name:2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE
- CAS Number:202865-80-3
- Molecular formula:C9H10BrFO
- Molecular Weight:233.08
2105-94-4
366 suppliers
$6.00/5g
67-63-0
1670 suppliers
$16.00/25ML
202865-80-3
78 suppliers
$32.00/1g
Yield: 99%
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 45; for 1 h;Reflux;
Steps:
20.1
Step 1: 4-bromo-2-fluoro-1-isopropoxybenzene To a solution of 4-bromo-3-fluorophenol (10 g, 52.35 mmol) in THF (100 ml), isopropyl alcohol (4.8 ml, 62.62 mmol) and triphenylphosphine (20.6 g, 78.52 mmol) were added and heated to 45'C followed by diisopropylazodicarboxylate (15.4 ml, 78.52 mmol). The mixture was refluxed for 1 h, concentrated and the residue was purified by column chromatography with ethyl acetate:petroleum ether to afford the title compound as a colourless liquid (13.1 g, 99%) which was used without purification in the next step.
References:
Rhizen Pharmaceuticals SA;Incozen Therapeutics Pvt. Ltd. US2011/281865, 2011, A1 Location in patent:Page/Page column 86
121219-03-2
285 suppliers
$13.00/5g
67-63-0
1670 suppliers
$16.00/25ML
202865-80-3
78 suppliers
$32.00/1g
75-30-9
279 suppliers
$15.00/1 g
2105-94-4
366 suppliers
$6.00/5g
202865-80-3
78 suppliers
$32.00/1g