2,4-DICHLORO-6-METHYL-3-NITROPYRIDINE synthesis
- Product Name:2,4-DICHLORO-6-METHYL-3-NITROPYRIDINE
- CAS Number:63897-12-1
- Molecular formula:C6H4Cl2N2O2
- Molecular Weight:207.01
4966-90-9
63897-12-1
General procedure for the synthesis of 2,4-dichloro-6-methyl-3-nitropyridine from 4-hydroxy-6-methyl-3-nitro-2-pyridone: (1) 4-hydroxy-6-methyl-3-nitro-2-pyridone (1.7 g, 10 mmol) was dissolved in 10 mL of phosphorus oxychloride (POCl3), heated to 95 °C, and the reaction was stirred for 1.5 hours. Upon completion of the reaction, excess POCl3 was removed by centrifugation.Subsequently, the reaction was quenched by slow addition of 100 mL of ice water. The reaction mixture was extracted with ethyl acetate (80 mL x 3). The organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1.773 g of yellow powdery product in 85.7% yield.
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63897-12-1
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: 72 percent / conc. HNO3; NaNO2 / acetic acid / 0.5 h / 20 °C
2: 64 percent / POCl3; Et3N / 1 h / Heating
References:
Stadlbauer;Fiala;Fischer;Hojas [Journal of Heterocyclic Chemistry,2000,vol. 37,# 5,p. 1253 - 1256]
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63897-12-1
115 suppliers
$65.00/100mg
4966-90-9
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$14.00/1g
63897-12-1
115 suppliers
$65.00/100mg
675-10-5
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63897-12-1
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$65.00/100mg
4966-90-9
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63897-12-1
115 suppliers
$65.00/100mg