2,4-Dichloro-7-methoxy-8-methylquinoline synthesis
- Product Name:2,4-Dichloro-7-methoxy-8-methylquinoline
- CAS Number:1108659-32-0
- Molecular formula:C11H9Cl2NO
- Molecular Weight:242.1
141-82-2
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857195-15-4
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1108659-32-0
21 suppliers
$954.00/5g
Yield:1108659-32-0 43%
Reaction Conditions:
with trichlorophosphate for 16 h;Heating / reflux;
Steps:
14.1; 13.B.3
Step 1: Preparation of 2,4-dichloro-8-methyl-7-methoxyquinoline 81. A mixture of 2-methyl-3-methoxyaniline hydrochloride (15 g, 1 eq.), malonic acid (12.06 g, 1.5 eq.), and phosphorus oxochloride (80 mL) was refluxed for 16 hrs. The reaction mixture was slowly poured into water and extracted with DCM. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude material was purified
References:
WO2009/14730,2009,A1 Location in patent:Page/Page column 123; 126-127
141-82-2
790 suppliers
$5.00/25g
19500-02-8
215 suppliers
$9.00/1g
1108659-32-0
21 suppliers
$954.00/5g