2-(4-FLUOROBENZYLAMINO)ETHANOL synthesis
- Product Name:2-(4-FLUOROBENZYLAMINO)ETHANOL
- CAS Number:22116-33-2
- Molecular formula:C9H12FNO
- Molecular Weight:169.2
P-fluorobenzaldehyde (24.8 g, 0.2 mol) and 2-aminoethanol (15.3 g, 0.25 mol) were added to a reaction flask containing methanol (250 ml), heated to reflux, and kept at 65 ° C for 4 h.The temperature was lowered, sodium borohydride (9.2 g 0.24 mol) was added, and the reaction was stirred, the reaction was completed, filtered, and concentrated.The fraction was collected to give 2-(4-fluorobenzylamino)ethanol as a colorless oily liquid (yield: 90.2%, purity 98.7%).
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22116-33-2
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Yield:22116-33-2 90.2%
Reaction Conditions:
Stage #1: 4-fluorobenzaldehyde;ethanolamine in methanol at 65; for 4 h;
Stage #2: with sodium tetrahydroborate
Steps:
7 Preparation of 2-(4-fluorobenzylamino)ethanol:
P-fluorobenzaldehyde (24.8 g, 0.2 mol) and 2-aminoethanol (15.3 g, 0.25 mol) were added to a reaction flask containing methanol (250 ml), heated to reflux, and kept at 65 ° C for 4 h.The temperature was lowered, sodium borohydride (9.2 g 0.24 mol) was added, and the reaction was stirred, the reaction was completed, filtered, and concentrated.The fraction was collected to give 2-(4-fluorobenzylamino)ethanol as a colorless oily liquid (yield: 90.2%, purity 98.7%).
References:
CN108129414,2018,A Location in patent:Paragraph 0047-0049
![Ethanol, 2-[[(4-fluorophenyl)methylene]amino]-](/CAS/20210305/GIF/635283-50-0.gif)
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22116-33-2
110 suppliers
$35.00/200μmol