2,5-Dibromobenzenamine synthesis
- Product Name:2,5-Dibromobenzenamine
- CAS Number:3638-73-1
- Molecular formula:C6H5Br2N
- Molecular Weight:250.92
3460-18-2
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$6.00/10g
3638-73-1
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$10.00/1g
Yield:3638-73-1 97%
Reaction Conditions:
Stage #1:1,4-dibromo-2-nitrobenzene with hydrogenchloride;tin(ll) chloride in ethanol;water at 20; for 3 h;Heating / reflux;
Stage #2: with sodium hydroxide in ethanol;water; pH=8 - 9
Steps:
38.2
A solution of 1 ,4-dibromo-2-nitrobenzene (64.1 mmol) in ethanol (40 mL) was added to a solution of tin(II) chloride hydrate (192 mmol) in concentrated hydrochloric acid (40 mL) and the reaction mixture was heated at reflux for 1 h. The reaction mixture was allowed to cool to rt and was maintained for an additional 2 h. The pH of the aqueous layer was adjusted to 8-9 with 50% sodium hydroxide and the resulting solution was extracted with ethyl acetate (3 x 200 mL), dried (sodium sulfate), and concentrated to provide 2,5-dibromobenzenamine in 97% yield as a yellow solid.
References:
MEMORY PHARMACEUTICALS CORPORATION WO2009/23844, 2009, A2 Location in patent:Page/Page column 129
106-37-6
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3638-73-1
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$10.00/1g
591-19-5
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3638-73-1
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$10.00/1g
615-55-4
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$16.00/1g
608-22-0
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