2,6-Dichloroisonicotinonitrile synthesis
- Product Name:2,6-Dichloroisonicotinonitrile
- CAS Number:32710-65-9
- Molecular formula:C6H2Cl2N2
- Molecular Weight:173
89281-13-0
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$21.75/1g
32710-65-9
161 suppliers
$11.00/250mg
Yield: 99%
Reaction Conditions:
with tetraethylammonium chloride;trichlorophosphate at 80; for 24 h;
Steps:
General preparation of carbonitriles 8 and 14.
General procedure: The appropriate carboxamide 7 or 13 (189 mg, 0.99 mmol) was subjected to catalytic amounts of tetraethylammonium chloride (5% w/w) and POCl3 (5 ml) and heated under reflux at 80°C for 24 h. Excess POCl3 was removed in vacuo to leave a crude residue which was diluted with dichloromethane (10 ml) and filtered. The filtrate was washed successively with saturated aqueous K2CO3 (2 x 5 ml) and distilled water (5 ml). After drying over anhydrous Na2SO4, the solvent was evaporated to yield carbonitrile 8 or 14 which was sufficiently pure for use in the next reaction without purification.
References:
Changunda, Charles R.K.;Rousseau, Amanda L.;Basson, Adriaan E.;Bode, Moira L. [Arkivoc,2021,vol. 2020,# 3,p. 152 - 170]
5398-44-7
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$6.00/1g
32710-65-9
161 suppliers
$11.00/250mg
42521-08-4
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$26.85/1gm:
32710-65-9
161 suppliers
$11.00/250mg
557-21-1
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$12.00/5g
408492-27-3
141 suppliers
$31.50/250mg
32710-65-9
161 suppliers
$11.00/250mg
2402-78-0
517 suppliers
$6.00/25g
32710-65-9
161 suppliers
$11.00/250mg