2,6-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE synthesis
- Product Name:2,6-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE
- CAS Number:883549-54-0
- Molecular formula:C12H11NO3
- Molecular Weight:217.22
67-56-1
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73568-29-3
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883549-54-0
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Yield:883549-54-0 78%
Reaction Conditions:
with potassium hydroxide at 60;
Steps:
1.1 General procedure for the synthesis of 2-methoxyquinoline-3-carbaldehydes (19-24)
General procedure: To a solution of KOH (75.7 mmol) in MeOH (100 mL) was added the corresponding 2-chloro-3-quinolinecarbaldehyde (52.2 mmol) with constant stirring. The mixture was heated under reflux for 2.5-6 h and then cooled to room temperature. The product was precipitated out by adding water (300 mL) and then collected by vacuum filtration. The dried crude was recrystalised in DCM to afford compounds in yields ranging from 42-89%.
References:
Bokosi, Fostino R.B.;Beteck, Richard M.;Mbaba, Mziyanda;Mtshare, Thanduxolo E.;Laming, Dustin;Hoppe, Heinrich C.;Khanye, Setshaba D. [Bioorganic and Medicinal Chemistry Letters,2021,vol. 38] Location in patent:supporting information
104-94-9
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$9.00/1g
883549-54-0
16 suppliers
$110.00/50mg
51-66-1
230 suppliers
$12.00/1mg
883549-54-0
16 suppliers
$110.00/50mg
73568-29-3
103 suppliers
$15.00/1g
124-41-4
722 suppliers
$12.00/25g
883549-54-0
16 suppliers
$110.00/50mg
73568-29-3
103 suppliers
$15.00/1g
883549-54-0
16 suppliers
$110.00/50mg