2,6-DIMETHYLISONICOTINIC ACID synthesis
- Product Name:2,6-DIMETHYLISONICOTINIC ACID
- CAS Number:54221-93-1
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
39965-81-6
115 suppliers
$36.00/250mg
54221-93-1
110 suppliers
$45.00/100mg
Yield:-
Reaction Conditions:
with sulfuric acid at 100; for 5 h;
Steps:
1.a 2,6-Dimethylisonicotinic Acid (2)
A mixture of 1 g (7.56 mmol) of (1) and 5 ml of concentrated sulfuric acid is heated at 100° C. for 5 hours. The resulting solution is then cooled on an ice bath, brought to pH 3.5 with 10 N sodium hydroxide and then concentrated to dryness. Extraction with ether for 48 hours (soxhlet) of a portion of the residue obtained gives 50 mg of 2,6-dimethylisonicotinic acid (2) for analysis. The remaining crude reaction product, not treated with ether, is used in its present form in the esterification reaction without further purification. [0133] NMR: 1H (D20); internal reference tBuOH 1.29 ppm. [0134] 2.82 (s, 6H, CH3); 8.05 (s, 2H, Py). [0135] MS (EI): 151 (M+, 100); 134 (M+-OH, 7.2); 106 (M+-CO2H, 16.4) [0136] MA: C8H9NO2+0.1 NaHSO4 (163.16) [0137] calculated: C 58.89H 5.62 N 8.58 O 23.53 [0138] found: C 58.73H 5.90 N 8.37 O 23.7
References:
US2004/92726,2004,A1 Location in patent:Page 7
1122-43-6
126 suppliers
$9.00/100mg
54221-93-1
110 suppliers
$45.00/100mg
1073-23-0
182 suppliers
$14.00/1g
54221-93-1
110 suppliers
$45.00/100mg
108-75-8
459 suppliers
$5.00/10g
54221-93-1
110 suppliers
$45.00/100mg
18206-06-9
86 suppliers
inquiry
54221-93-1
110 suppliers
$45.00/100mg