2-Amino-4-cyanopyridine synthesis
- Product Name:2-Amino-4-cyanopyridine
- CAS Number:223463-02-3
- Molecular formula:C6H5Br2NO
- Molecular Weight:266.92
2016-99-1
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223463-02-3
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Yield:223463-02-3 98%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 50; for 0.166667 h;
Steps:
6.1 Step 1: (2,6-Dibromopyridin-4-yl) methanol
After cooling 2,6-dibromoisonicotinic acid (25 g, 89 mmol) dissolved in tetrahydrofuran (THF) (89 mL) to 0 ° C.,Borane THF complex was added dropwise and then the mixture was heated at 50 ° C. for 3 hours. The reaction was cooled, methanol (MeOH) (30 mL) was added and the reaction was then heated to 50 ° C. for 10 minutes. The mixture was then concentrated and chased with an additional 50 mL of MeOH. The residue was partitioned between ethyl acetate and saturated aqueous Na2CO3. The combined organic phases were dried over anhydrous MgSO 4, filtered and concentrated to give the product (23.26 g, 87 mmol, 98% yield).
References:
JP6557436,2019,B1 Location in patent:Paragraph 0393; 0394; 0395
119308-57-5
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223463-02-3
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