2-Aminoethyldiisopropylamine synthesis
- Product Name:2-Aminoethyldiisopropylamine
- CAS Number:121-05-1
- Molecular formula:C8H20N2
- Molecular Weight:144.26
54714-49-7
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121-05-1
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Yield:121-05-1 83.7%
Reaction Conditions:
with lithium aluminium tetrahydride;nickel dichloride in tetrahydrofuran at 5 - 65; for 5 h;Solvent;Reagent/catalyst;Temperature;
Steps:
9
Reduction reaction: 70 g (0.5 mol) of N, N-diisopropylaminoacetonitrile and 500 ml of tetrahydrofuran were added to a 1000 ml three-necked flask, and the temperature of the system was lower than 5 ° C,Batch slowly joinLithium aluminum tetrahydrate (0.7 mol),Nickel chloride O.Olmol, the control temperature is not higher than 15 ° C, after the completion of natural heating to room temperature to continue stirring lh, and then heated to 65 ° C reaction 5h, stirring with water, filtered and concentrated to dry after atmospheric distillation, ~ 172 ° C fractions, to be N, N-diisopropylethylenediamine 60.3 g, colorless liquid, the yield of 83.7%, gas purity 98.4%.
References:
Jiangsu Siweisen Bio-pharmaceutical Engineering Research Center Co., Ltd.;Zhangjiagang Weisheng Bio-pharmaceutical Co., Ltd.;Wuyang Weisen Bio-pharmaceutical Co., Ltd.;Zhang Mei;Peng Xuedong;Zhao Jinzhao;Li Weidong CN107216256, 2017, A Location in patent:Paragraph 0042; 0044; 0046-0048; 0050; 0052
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85262-27-7
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121-05-1
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27453-38-9
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121-05-1
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108-18-9
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121-05-1
287 suppliers
$6.00/5g