2-AMINOMETHYL-3-PHENYL-PROPIONIC ACID synthesis
- Product Name:2-AMINOMETHYL-3-PHENYL-PROPIONIC ACID
- CAS Number:95598-13-3
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
![Butanedioic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-2-(phenylmethyl)-, 1,4-diethyl ester](/CAS/20210305/GIF/943321-35-5.gif)
943321-35-5
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95598-13-3
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Yield:95598-13-3 100%
Reaction Conditions:
with hydrogenchloride;acetic acid in water at 120; for 48 h;
Steps:
8.b
A solution of diethyl 2-[(1 ,3-dioxo-1 ,3-dihydro-2/-/-isoindol-2-yl)methyl]-2-(phenylmethyl)butanedioate (13 g, 31.8 mmole) in cone. HCI (125 mL) and HOAc (30 mL) was sealed in a 1 L screwcap reaction vessel and the contents heated to 1200C for 48h. The reaction solution was concentrated under vacuum and the resulting solids washed with Et2O affording the title compound (quant.) as a white solid: LCMS (ES) m/z 181 (M+H)+.
References:
WO2007/76423,2007,A2 Location in patent:Page/Page column 59
5669-19-2
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95598-13-3
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131932-59-7
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95598-13-3
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120539-98-2
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95598-13-3
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4656-94-4
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95598-13-3
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