2-(AMINOOXY)ETHANOL synthesis
- Product Name:2-(AMINOOXY)ETHANOL
- CAS Number:3279-95-6
- Molecular formula:C2H7NO2
- Molecular Weight:77.08
32380-69-1
3279-95-6
General procedure for the synthesis of 2-aminooxyethanol from 2-(2-hydroxyethoxy)isoindoline-1,3-dione: A mixed solution of the product of Example 13a (15.57 g, 75.2 mmol) and hydrazine hydrate (5.4 mL, 0.11 mol) in methanol (150 mL) was heated to 70 °C and reacted for 1.5 hours. After completion of the reaction, it was cooled to room temperature and chloroform (100 mL) was added to the reaction mixture. The resulting slurry was filtered and washed with chloroform (100 mL x 2). The filtrates were combined and concentrated, and the residue was distilled at 75-80 °C under vacuum at 0.025 mmHg to give the colorless oily product 2-aminooxyethanol (4.54 g, 78% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) δ 3.78 (s, 4H) and 13C NMR (75 MHz, CDCl3) δ 76.3,60.7.
32380-69-1
30 suppliers
inquiry
3279-95-6
123 suppliers
$34.00/100mg
Yield: 86%
Reaction Conditions:
with hydrazine hydrate in ethanol for 2 h;Heating;
References:
Dhanak, Dashyant;Reese, Colin B. [Journal of the Chemical Society. Perkin transactions I,1987,p. 2829 - 2832]
3279-94-5
0 suppliers
inquiry
3279-95-6
123 suppliers
$34.00/100mg
83495-51-6
14 suppliers
inquiry
3279-95-6
123 suppliers
$34.00/100mg
23156-61-8
0 suppliers
inquiry
3279-95-6
123 suppliers
$34.00/100mg