2-BROMO-4-(4-BROMO-PHENYL)-THIAZOLE synthesis
- Product Name:2-BROMO-4-(4-BROMO-PHENYL)-THIAZOLE
- CAS Number:98591-51-6
- Molecular formula:C9H5Br2NS
- Molecular Weight:319.02
65679-14-3
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Yield:98591-51-6 84%
Reaction Conditions:
Stage #1: 1-(4-bromophenyl)-2-thiocyanatoethanonewith hydrogen bromide in acetic acid at 20; for 7 h;
Stage #2: with sodium hydroxide in water;acetic acid at 20; for 17 h;
Steps:
1.2
Step 2: 2-Bromo-4-(4-bromophenyl)-1,3-thiazole A suspension of 2-(4-bromophenyl)-2-oxoethyl thiocyanate (5.12 g, 20.0 mmol), prepared in the previous step, in 30 mL of 30% hydrogen bromide in acetic acid was stirred under nitrogen at room temperature for 7 h. The yellow suspension was poured into 200 mL of 1 N NaOH (exotherm) and the mixture stirred at room temperature for 17 h. The solid present was collected by filtration, rinsed with water, ice-cold ethanol, hexane and then dried under high vacuum to give 2-bromo-4-(4-bromophenyl)-1,3-thiazole (5.36 g, 84%) as a light yellow solid, mp 117-119° C.; MS (ES) m/z 318/320/322 [M+H]+.
References:
US2008/45518,2008,A1 Location in patent:Page/Page column 14
99-73-0
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