2-bromo-4-chloropropiophenone synthesis
- Product Name:2-bromo-4-chloropropiophenone
- CAS Number:877-37-2
- Molecular formula:C9H8BrClO
- Molecular Weight:247.52
6285-05-8
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877-37-2
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Yield:877-37-2 98%
Reaction Conditions:
with bromine;hydrogen bromide in methanol at 20; for 110 h;Inert atmosphere;
Steps:
1.a.1
Step 1. 2-Bromo-4'-chloropropiophenone (1Of). 4'-Chloropropiophenone 9f(4.58 g, 0.027 mol) was dissolved in 30 mL of methanol at room temperature in a 250 mL flask equipped with a magnetic stir bar. Bromine (1.67 mL, 32.6 mmol) was added over a period of 10 min. Seven drops of 48% hydrobromic acid were added, and the reaction mixture was stirred under N2. After HO h, the solution was transferred to a separatory funnel, saturated sodium bicarbonate solution was added, and the aqueous layer was extracted with methylene chloride. The organic layer was dried (Na2SO4) and filtered. The solvent was removed under reduced pressure to give 6.60 g (98%) of 1Of as an orange oil. 1H NMR (CDCl3) δ 8.00-7.94 (d, 2H), 7.50-7.44 (d, 2H), 5.27-5.19 (q, IH), 1.92-1.89 (d, 3H).
References:
WO2010/121022,2010,A1 Location in patent:Page/Page column 66-67
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877-37-2
155 suppliers
$65.00/250mg
108-90-7
697 suppliers
$10.00/25G
877-37-2
155 suppliers
$65.00/250mg