2-bromo-5-ethoxybenzaldehyde synthesis
- Product Name:2-bromo-5-ethoxybenzaldehyde
- CAS Number:43192-32-1
- Molecular formula:C9H9BrO2
- Molecular Weight:229.07
2973-80-0
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75-03-6
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43192-32-1
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$38.00/250mg
Yield:-
Reaction Conditions:
with caesium carbonate in dimethyl sulfoxide at 20; for 2 h;
Steps:
93
2-Bromo-5-hydroxybenzaldehyde (0.96 g, 4.8 mmol) was dissolved in anhydrous DMSO (10 mL). Iodoethane (0.50 niL, 6.2 mmol) and Cs2CO3 (1.9 g, 6.3 mmol) were added and the mixture stirred at room temperature for 1.5 hours. Additional Cs2CO3 (1.45 g, 4.8 mmol) was added to the reaction mixture and then was stirred for 30 minutes. The reaction mixture was diluted with H2O and EtOAc and the layers were separated. Brine was added to the aqueous layer and it was extracted twice with EtOAc. The combined organics were washed with IM NaOH twice and brine thrice, and then was dried over MgSO4. The solution was vacuum-filtered through Celite and concentrated in vacuo to give 1.08 g of 2-bromo-5- ethoxybenzaldehyde.
References:
WO2006/55525,2006,A2 Location in patent:Page/Page column 90
64-67-5
382 suppliers
$14.00/5g
2973-80-0
407 suppliers
$6.00/1g
43192-32-1
36 suppliers
$38.00/250mg