2-Chloro-3,5-dinitrobenzoic acid synthesis
- Product Name:2-Chloro-3,5-dinitrobenzoic acid
- CAS Number:2497-91-8
- Molecular formula:C7H3ClN2O6
- Molecular Weight:246.56
118-91-2
677 suppliers
$8.50/5g
2497-91-8
138 suppliers
$23.89/25g
Yield: 73.5%
Reaction Conditions:
with fuming sulphuric acid;sulfuric acid;nitric acid at 0 - 125; for 7 h;
Steps:
2 Preparation of intermediate 2a 2-chloro-3,5-dinitrobenzoic acid
2-chlorobenzoic acid (7.8 g, 50 mmol) was dissolved in 25 mL of concentrated sulfuric acid.Stir until completely dissolved,Cool in ice bath to 0 ° C, Slowly add 15 mL of fuming nitric acid to the reaction system. After 30 minutes, Continue to stir at 0 ° C for 0.5 hours. Then the temperature was raised to 125 ° C and the reaction was stirred for 6 hours. Add 250 mL of ice water to the reaction system. Precipitate in white, filter, wash, dryDrying, the intermediate 2-chloro-3,5-dinitrobenzoic acid 2a, The yellow solid was 9.04 g, and the yield was 73.5%.
References:
Chinese Academy Of Medical Sciences Pharmaceutical Institute;Huang Haihong;Zhang Xinwei;Yin Dali CN104211708, 2018, B Location in patent:Paragraph 0117-0120
609-99-4
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$12.00/1mg
2497-91-8
138 suppliers
$23.89/25g
2516-96-3
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$6.00/25g
2497-91-8
138 suppliers
$23.89/25g
3970-35-2
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$6.00/250mg
2497-91-8
138 suppliers
$23.89/25g
2516-96-3
458 suppliers
$6.00/25g
2497-91-8
138 suppliers
$23.89/25g
97-00-7
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$17.67/10gm: