2-Chloro-4-Bromo-3-Picoline synthesis
- Product Name:2-Chloro-4-Bromo-3-Picoline
- CAS Number:128071-86-3
- Molecular formula:C6H5BrClN
- Molecular Weight:206.47
73583-37-6
74-88-4
128071-86-3
2-Chloro-4-bromopyridine (5 g, 26.19 mmol, 1.0 eq.) was dissolved in 30 ml of anhydrous tetrahydrofuran and a freshly prepared lithium diisopropylammonium solution (50 ml, 28.8 mmol, 1.1 eq.) was added slowly and dropwise at -70 °C. After 1 hour of reaction, keeping the temperature at -70 °C, iodomethane (4.087 g, 28.8 mmol, 1.1 eq.) was added. After 50 min at low temperature, the reaction was quenched with saturated sodium bicarbonate solution, extracted with ethyl acetate, the organic phase was dried with anhydrous sodium sulfate and concentrated to give the solid compound 4-bromo-2-chloro-3-methylpyridine (5.22 g, yield: 97.2%).
73583-37-6
336 suppliers
$9.00/1g
74-88-4
348 suppliers
$15.00/10g
128071-86-3
77 suppliers
$25.00/100mg
Yield: 97.2%
Reaction Conditions:
Stage #1:2-chloro-4-bromopyridine with lithium diisopropyl amide in tetrahydrofuran at -70; for 1 h;
Stage #2:methyl iodide in tetrahydrofuran at -70; for 0.833333 h;
Steps:
46.46a Step 46a: 4-bromo-2-chloro-3-methylpyridine (4-bromo-2-chloro-3-methylpyridine) (Compound 402-25) Preparation :
4-bromo-2-chloropyridine (5 g, 26.19 mmol, 1.0 eq.) was dissolved in 30 ml of dry tetrahydrofuran, and under conditions of -70 °C, slowly added dropwise a freshly prepared lithium diisopropylamide solution (50 ml, 28.8 mmol, 1.1 equiv.). Kept at -70 °C, after reaction for one hour, iodomethane (4.087 g, 28.8 mmol, 1.1 eq). After 50 minutes reaction at low temperature, quenched with saturated sodium bicarbonate solution, the reaction, extracted with ethyl acetate, the organic phase was dried over anhydrous sodium sulfate, and concentrated to give a solid compound 4-bromo-2-chloro-3-methylpyridine (5.22 g, yield: 97.2%).
References:
Guangzhou Kaisheng Beite Pharmaceutical Co., Ltd.;Cai, Xiong;Qian, Changgeng;Liu, Bin;Li, Junqi;Lin, Mingsheng;Qing, Yuanhui;Weng, Yunwo;Wang, Yanyan;Xue, Weicai;You, Huajin;Zhou, Shiqing CN105622638, 2016, A Location in patent:Paragraph 0381
52200-48-3
374 suppliers
$11.00/1g
74-88-4
348 suppliers
$15.00/10g
128071-86-3
77 suppliers
$25.00/100mg