2-Chloro-5-(chloromethyl)pyridine synthesis
- Product Name:2-Chloro-5-(chloromethyl)pyridine
- CAS Number:70258-18-3
- Molecular formula:C6H5Cl2N
- Molecular Weight:162.02
150807-86-6
70258-18-3
General procedure for the synthesis of 2-chloro-5-chloromethylpyridine from the compound (CAS:150807-86-6): 18 g (0.1 mol) of 2-chloro-2-chloromethyl-4-cyano-butanal was dissolved in 50 ml of toluene, and 33 g (1.1 eq.) of solid phosgene was added to the toluene solution. The reaction mixture was stirred at 50°C for 5 hours. Upon completion of the reaction, the mixture was cooled to facilitate crystallization to afford the acetamiprid intermediate 2-chloro-5-chloromethylpyridine in 97% yield. Subsequently, the acetamiprid prodrug was further synthesized in 95% yield through methylation and esterification reaction steps.
150807-86-6
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70258-18-3
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Yield:70258-18-3 97%
Reaction Conditions:
with phosgene in toluene at 50; for 6 h;Temperature;
Steps:
2; 7 Example 2
18 g (0.1 mol) of 2-chloro-2-chloromethyl-4-cyanobutanal were addedDissolved in 50 ml of toluene,A solution of 33 g (1.1 eqiv)Solid phosgene toluene solution,The reaction was incubated at 50 ° C for 5 hours. Cooling crystallization,Acetamiprid intermediate 2-chloro-5-chloromethylpyridine, yield 97%.Then methylated, esterified to synthesize acetamiprid original drug,Yield 95%.
References:
CN106699646,2017,A Location in patent:Paragraph 0012; 0013; 0014; 0015; 0016; 0017; 0018-0020
18368-64-4
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70258-18-3
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70258-18-3
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70258-18-3
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