Yield:3272-96-6 42%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium carbonate in water;

Steps:

5.A Alternative Preparation of a Compound of Formula I

A. Preparation of 2-chloroacetamidoxime: Hydroxylamine hydrochloride (85 g, 1.22 mol) in water (250 mL) was treated with sodium carbonate (60 g, 0.58 mol), and the solution cooled to 0° C. Chloroacetonitrile (100 g, 1.32 mol) was added over 2 hours, and the reaction allowed to proceed for an additional 2 hours. The resultant slurry was filtered, washed with minimal cold H₂O, and dried to yield 2-chloroacetamidoxime (55.0 g, 42%).

References:

US2003/176447,2003,A1