2-Chlorobenzoxazole synthesis
- Product Name:2-Chlorobenzoxazole
- CAS Number:615-18-9
- Molecular formula:C7H4ClNO
- Molecular Weight:153.57
2382-96-9
615-18-9
General procedure for the synthesis of 2-chlorobenzoxazole from 2-mercaptobenzoxazole: 2-mercaptobenzoxazole (10 mmol, 1.51 g) was suspended in SOCl2 (50 mL), and a few drops of DMF were added as catalyst. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the solvent was removed by evaporation. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/EtOAc, 10:1) to afford the target compound as a colorless oil in 69.7% yield.
2382-96-9
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615-18-9
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Yield:615-18-9 90%
Reaction Conditions:
with chlorine
Steps:
5 EXAMPLE 5
EXAMPLE 5 Example 1 is repeated, except that 2-chlorobenzoxazole is initially introduced, a temperature range of 20°-40° C. is used from the start, 830 g of 2-mercaptobenzoxazole are added and 586 g of chlorine are passed in. About 910 g of 2-chlorobenzoxazole are obtained after distillation under a water-jet vacuum at 107° C. Traces of ring-chlorinated product can be detected in the distillation residue. Yield: 90% of theory.
References:
Cassella Aktiengesellschaft US4517370, 1985, A
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615-18-9
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2382-96-9
307 suppliers
$6.00/5g
615-18-9
255 suppliers
$5.00/1g
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615-18-9
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615-18-9
255 suppliers
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