2-Fluoro-3,6-diiodopyridine synthesis
1synthesis methods
- Product Name:2-Fluoro-3,6-diiodopyridine
- CAS Number:1245321-31-6
- Molecular formula:C5H2FI2N
- Molecular Weight:348.88
Yield:113975-22-7 82% ，1245321-31-6 15%
Reaction Conditions:
Stage #1: 2-fluoropyridinewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium;zinc dichloro(N,N,N′,N′-tetramethylethylenediamine) in tetrahydrofuran;hexane at 20; for 2 h;Inert atmosphere;
Stage #2: with iodine in tetrahydrofuran;hexane at 20;Inert atmosphere;regioselective reaction;Concentration;
References:
Hedidi, Madani;Bentabed-Ababsa, Ghenia;Derdour, A?cha;Halauko, Yury S.;Ivashkevich, Oleg A.;Matulis, Vadim E.;Chevallier, Floris;Roisnel, Thierry;Dorcet, Vincent;Mongin, Florence [Tetrahedron,2016,vol. 72,# 17,p. 2196 - 2205]