ChemicalBook CAS DataBase List 2-Fluoro-4-methoxybenzoic acid

2-Fluoro-4-methoxybenzoic acid synthesis

11synthesis methods

Product Name:2-Fluoro-4-methoxybenzoic acid
CAS Number:394-42-3
Molecular formula:C8H7FO3
Molecular Weight:170.14

331-64-6

394-42-3

Step a) 2-fluoro-4-methoxybenzaldehyde (15 g, 97.4 mmol) was added to a mixture of silver oxide (Ag2O, 13.5 g, 58.4 mmol), sodium hydroxide (NaOH, 19.5 g, 487 mmol), and water (200 mL) preheated to 55 °C. The reaction mixture was stirred at 55 °C for 1 h. Subsequently, it was filtered and the precipitated solid was washed with hot water (10 mL). The filtrate was slowly added to 5N hydrochloric acid (HCl) pre-cooled to 0°C under vigorous stirring. The precipitated solid was filtered, washed with water and dried to give 2-fluoro-4-methoxybenzoic acid as a white solid (13.6 g, 82% yield, melting point 194-196°C); mass spectrum (MS) showed m/e 169 (M-H)+.

331-64-6 Synthesis

331-64-6
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$14.00/1g

394-42-3
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$21.21/1gm:

Yield:394-42-3 82%

Reaction Conditions:

with hydrogenchloride;sodium hydroxide;Ag₂O in water

Steps:

22.a Step a) 2-Fluoro-4-methoxybenzoic acid
Step a) 2-Fluoro-4-methoxybenzoic acid Into a warm (55° C.) mixture of Ag₂O (13.5 g, 58.4 mmol), NaOH (19.5 g, 487 mmol) and water (200 mL) was added 2-fluoro-4-methoxybenzaldehyde (15 g, 97.4 mmol). The mixture was stirred for 1 h, filtered off and the precipitated solids were washed with hot water (10 mL). The filtrate was added slowly into cold (0° C.) HCl (5N) with vigorous stirring. The precipitated solid was filtered, washed with water and dried to give a white solid (13.6 g, 82% yield, m.p. 194-196° C.); MS m/e 169 (M-H)⁺.

References:

Wyeth US2003/199562, 2003, A1

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74457-86-6 Synthesis