2-Fluoro-6-nitrophenylacetic acid synthesis
- Product Name:2-Fluoro-6-nitrophenylacetic acid
- CAS Number:136916-19-3
- Molecular formula:C8H6FNO4
- Molecular Weight:199.14
866209-62-3
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136916-19-3
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Yield:136916-19-3 54%
Reaction Conditions:
with hydrogenchloride;water for 4 h;Heating / reflux;
Steps:
99.3
Step 3: 2-(6-Fluoro-2-nitro-phenyl)-malonic acid dimethyl ester (12 g, 44 mmol) in a 6N aqueous solution of hydrochloric acid (200 mL) was heated at reflux for 4 hours. The mixture was cooled, diluted with 250 mL of water and extracted with diethyl ether. The ethereal layer was dried over anhydrous magnesium sulfate, and concentrated in vacuo. Crystallization from 5% ethyl acetate/hexane gave 7.6 g of (6-fluoro-2-nitro-phenyl)-acetic acid (54%). MS (ESI) m/z 200 ([M+H]+).
References:
US2005/222148,2005,A1 Location in patent:Page/Page column 59
872141-24-7
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$150.00/250mg
136916-19-3
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6921-22-8
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$26.00/1g
136916-19-3
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