2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE synthesis
- Product Name:2'-HYDROXY-4',6'-DIMETHOXYACETOPHENONE
- CAS Number:90-24-4
- Molecular formula:C10H12O4
- Molecular Weight:196.2
Yield:90-24-4 100%
Reaction Conditions:
with potassium carbonate in acetone for 3 h;Reflux;
Steps:
To a refluxing solution of 2,4,6-trihydroacetophenone-monohydrate (10 g, 53.7 mmol) and K2CO3 (15 g, 108.7 mmol) in acetone (150 mL), (CH3)2SO4 was added at three hour intervals (3 x 3.5 mL, 40.0 mmol). The solution was filtered and the solvent was evaporated to afford 2,4-dimethoxy-6-hydroxyacetophenone as a yellow solid (98%).
References:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;UNIVERSIDAD PERUMA CAYETANO HEREDIA;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD);THE JOHNS HOPKINS UNIVERSITY;HAMMOND, Gerald, B.;APONTE, Jose, C.;GILMAN, Robert, H.;SAUVAIN, Michel, Henri-Auguste;VAISBERG, Abraham WO2010/19861, 2010, A1 Location in patent:Page/Page column 38; 50
500-99-2
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75-36-5
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90-24-4
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500-99-2
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64-19-7
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90-24-4
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90-24-4
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