2-HYDROXY-4-METHYLQUINOLINE synthesis
- Product Name:2-HYDROXY-4-METHYLQUINOLINE
- CAS Number:607-66-9
- Molecular formula:C10H9NO
- Molecular Weight:159.18
491-35-0
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607-66-9
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Yield:607-66-9 94%
Reaction Conditions:
with water;chloroacetic acid ethyl ester in ethyl acetate for 0.416667 h;Microwave irradiation;
Steps:
3 Example 3: Preparation of 4-methyl-2-(1H)-quinolinone
In a 50mL pressure-resistant reaction tube, 4-3.4% quinoline was added in sequence, Ethyl chloroacetate 1.23g, Distilled water 0.54g, 20 ml of ethyl acetate, The resulting mixture was subjected to microwave irradiation for 25 minutes in a 300 W microwave stirring reaction apparatus. Washing the reaction solution with hot water, Liquid separation, Collect organic phase, Ethyl acetate and ethyl chloroacetate were removed under reduced pressure. Recrystallization to give the corresponding 4-methyl-2-(1H)-quinolinone 1.50g, The yield was 94%.
References:
Hunan University of Science and Engineering;Changsha University of Science and Technology;He Weimin;Cao Zhong;Lu Linghui;Peng Sha;He Weibao;Zeng Fei;Bao Wenhu;Wang Yi CN108503582, 2018, A Location in patent:Paragraph 0065; 0066
32315-10-9
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52562-19-3
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$112.00/5g
607-66-9
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$8.00/5g
102-01-2
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607-66-9
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4053-40-1
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607-66-9
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4876-10-2
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607-66-9
198 suppliers
$8.00/5g