2-HYDROXY-9-FLUORENONE synthesis
- Product Name:2-HYDROXY-9-FLUORENONE
- CAS Number:6949-73-1
- Molecular formula:C13H8O2
- Molecular Weight:196.2
3096-56-8
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6949-73-1
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Yield: 99.9%
Reaction Conditions:
with lithium hydroxide monohydrate;N1-(4-hydroxy-2,6-dimethylphenyl)-N2-(4-hydroxy-3,5-dimethylphenyl)oxalamide;copper dichloride in water;dimethyl sulfoxide at 100; for 4 h;Reagent/catalyst;
Steps:
1-3 Synthesis of 2-hydroxyfluoren-9-one using copper (II) chloride
2-bromofluoren-9-one (Tokyo Chemical Industry Co., Ltd., 4.13 g, 16 mmol), lithium hydroxide monohydrate(1.41 g, 34 mmol), copper (II) chloride (45 mg, 0.33 mmol), N, N'-bis (2,6-dimethyl-4-hydroxyphenyl) oxamide (106 mg, 0.33 mmol) and DMSO / The mixture of water (25.6 mL / 6.4 mL) was heated and stirred at 100 ° C. for 4 hours. After cooling to room temperature,The reaction mixture is poured into 0.2 M hydrochloric acid (150 mL) andThe resulting red solid was collected by filtration and dried in vacuo (105 ° C., overnight).The target 2-hydroxyfluoren-9-one was obtained as a red solid (yield: 3.14 g, 99.9%,HPLC purity: 97.4%).
References:
Osaka Gas Chemical Co., Ltd.;Yamagata, Kenichi JP2019/77634, 2019, A Location in patent:Paragraph 0101-0105
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6949-73-1
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$32.00/100mg
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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6949-73-1
91 suppliers
$32.00/100mg
1000210-73-0
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inquiry
6949-73-1
91 suppliers
$32.00/100mg