2-Isopropyl-4-bromo-5-methylphenol synthesis
- Product Name:2-Isopropyl-4-bromo-5-methylphenol
- CAS Number:15062-34-7
- Molecular formula:C10H13BrO
- Molecular Weight:229.11
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Yield: 82%
Reaction Conditions:
with bromine in acetic acid at 0 - 20; for 6 h;
Steps:
2.1 (1) Synthesis of intermediate 5-methyl-2-isopropyl-4-bromophenol
1.218 g of thymol was dissolved in 20 mL of acetic acid, and the resulting solution was cooled to 0 °C.0.51 mL of Br2was slowly added over 20 minusing a constant pressure droppingfunnel, and the resulting mixture was stirred at room temperature for a further 6 h.The reactionshould be poured into 50mL of ice water, the extracted three times with 30mL of dichloromethane, the organic phases were combined, dried and concentrated using eluent (Stonepetroleum ether: 1: ethyl acetate = 40) column chromatography to give Intermediate 5 -Methyl-2-isopropyl-4-bromophenol, yield 82%, pale yellowoil.
References:
Yunnan Agricultural University;Su Fawu;Ye Min;Wang Kaibo;Fan Liming;Zha Yougui CN109942427, 2019, A Location in patent:Paragraph 0050-0053
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
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